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Salinomycin. A polyether ionophore antibiotic. Phase of research. Potential treatment - pre-clinical evidence. How it helps. Antiviral. Drug status.
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A team of researchers at the Genomics Research Center, Academia Sinica, Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use. salinomycin, reduces the proportion of CSCs [cancer stem cells] by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. 2019-05-27 Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.
En i förväg planerad klinisk studie av säkerhet, effektivitet eller optimalt doseringsschema för ett eller flera diagnostiska, terapeutiska eller profylaktiska läkemedel, apparater eller tekniker, utförd på människor som valts ut enligt fördefinierade urvalskriterier och observeras för förutbestämda indikationer In Denmark, clinical trials must also be notified to a research ethics committee, which performs an overall assessment of the trial's ethical aspects. Before a clinical trial can be started, approvals must be obtained from both a research ethics committee and the Danish Medicines Agency.
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2021-04-21 · Clinical Trials Information System reaches major milestone towards go-live and application of the Clinical Trial Regulation News 21/04/2021 EMA’s Management Board confirmed that the clinical trial EU Portal and Database, one of the main deliverables of the Clinical Trial Regulation and the key component of the Clinical Trial Information System (CTIS), is now fully functional and on track to Se hela listan på drugs.com Pragmatic trials may test the same intervention as an explanatory trial, but they are conducted in real-world clinical practice settings, with typical patients and by qualified clinicians, who may not, however, have a research background. Economics. Clinical trial costs vary depending on trial phase, type of trial, and disease studied.
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Analogously, our data also showed that the cytotoxicity of salinomycin on the UM cells is about 11~21-fold as high as that of the normal retinal pigmented epithelium cells, which implied the safety of salinomycin used in treatment of UM. Five experiments were conducted to test the anticoccidial efficacy of salinomycin (AHR-3096C, A. H. Robins) at 66 ppm and its compatibility with roxarsone (50 ppm) under floor pen conditions Monensin (100, 121 ppm), lasalocid (75, 125 ppm), and shuttle programs of salinomycin-monensin (66/100 ppm) or monensin-salinomycin (100/66 ppm) were included for comparison. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods: Primary tumor-initiating cells (TIC) isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell , showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis.
The way clinical trials are conducted in the European Union (EU) will undergo a major change when the Clinical Trial Regulation (Regulation (EU) No 536/2014) comes into application. The Regulation harmonises the assessment and supervision processes for clinical trials throughout the EU, via a Clinical Trials Information System (CTIS). Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. Collectively, the results of this pre-clinical study indicate that salinomycin alone or in combination with 5-fluorouracil and oxaliplatin exerts increased antitumoral activity compared to common chemotherapy.
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Thinking about joining a clinical trial? Clinical research has led to the discover As well as phase 1, 2 and 3 trials, other types of trials include pilot studies and feasibility studies as well as observational studies. Together we will beat cancer About cancer Cancer types Cancers in general Causes of cancer Coping with Clinical trials offered by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. We are experiencing extremely high call volume related to COVID-19 vaccine interest.
This document provides guidance on these aspects. 4. EU Member States, contracting States of the European Economic Area (EEA) (2) and persons who request auth orisation of a clinical trial (applicants), notify substantial amendments, and declare the end of a clinical trial in the
Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. Low-dose salinomycin induces anti-leukemic responses in AML and MLL Gary D R Roulston, Charlotte L Burt, Laura M J Kettyle, Kyle B Matchett, Heather L Keenan, Nuala M Mulgrew, Joanne M Ramsey, Caoifa Dougan, John McKiernan, Ivan V Grishagin, Ken I Mills , Alexander Thompson
2019-02-14 · The aim of the present pre-clinical study was to investigate the impact of salinomycin on patient-derived colorectal cancer initiating cells.
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This document provides guidance on these aspects. 4. EU Member States, contracting States of the European Economic Area (EEA) (2) and persons who request auth orisation of a clinical trial (applicants), notify substantial amendments, and declare the end of a clinical trial in the Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells.
The usage of salinomycin in veterinary medicine can be traced back to 1980s as a broad spectrum antimicrobial agent with activity against gram-positive bacteria, fungi, and parasites [4–6].
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RESEARCH ARTICLE Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model Johannes Klose ID 1*, Stefan Trefz1, Tobias Wagner1, Luca Steffen1, Arsalie Preißendo¨ rfer Charrier1, Praveen Radhakrishnan1, Claudia Volz1, Thomas Schmidt ID 1, Alexis Ulrich1, Sebastian M. Dieter2, Claudia Ball3, Hanno Glimm2,3,4,5, Martin Schneider1 1 Department of General, Visceral and The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future salinomycin's mechanism of action is of great importance to understanding salinomycin's safety and potential for clinical application.
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The biological activity of these compounds is evaluated against transformed human mammary epithelial HMLER CD24 low /CD44 high cells, a well‐established model of breast CSC, and HMLER CD24 high /CD44 low cells deprived of CSC properties. Se hela listan på laegemiddelstyrelsen.dk Se hela listan på cancerresearchuk.org Valiant antibodies salinomycin Antibodies Salinomycin, supplied by Valiant, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations.
Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways. In vitro: Several hepatocellular carcinoma (HCC) cell lines were treated with Sal. Five experiments were conducted to test the anticoccidial efficacy of salinomycin (AHR-3096C, A. H. Robins) at 66 ppm and its compatibility with roxarsone (50 ppm) under floor pen conditions Monensin (100, 121 ppm), lasalocid (75, 125 ppm), and shuttle programs of salinomycin-monensin (66/100 ppm) or monensin-salinomycin (100/66 ppm) were included for comparison. Sporadic cancer cell lines with hyperactive mTORC1 signalling were also susceptible to this nelfinavir/salinomycin drug combination.